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DNJ competitively inhibits the intestinal brush border enzyme alpha-glucosidase, slowing the hydrolysis of complex carbohydrates to monosaccharides and reducing the rate and magnitude of post-prandial glucose absorption the same mechanism as the pharmaceutical compound acarbose, but derived from a botanical source

While therian mammal GCG genes encode identical GLP-1 protein sequences, there are significant changes in the platypus Gcg ortholog

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& Carter, D

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