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SGLT2 Inhibitors and GLP-1 Receptor Agonists: Established and Emerging Indications

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Perspectives and conclusions Tirzepatide has demonstrated marked and dose-dependent reductions in glycemic parameters in patients with T2D that, according to the present study data, surpass the effects of the GLP-1RA dulaglutide and semaglutide (54, 66, 67, 71)

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In patients with T2DM who are poorly controlled by metformin, increasing DUL from 1.5mg to 3.0mg or 4.5mg can provide glycosylated hemoglobin and weight loss related to clinically relevant doses and has similar safety (111)

Recently, a comprehensive cohort study utilizing data from the Korean National Health Insurance Service from 2004 to 2021 indicated no significant correlation between GLP-1 RAs and the incidence of new-onset malignancies, with a median follow-up of 8 years [109]