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The NHS and British Dietetic Association advise against unsupervised extreme or very low-calorie fasting regimens

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While the exact cause is not fully understood, genetic predisposition, stress, and other immune-related factors are believed to contribute to its onset

A study in mice with PCOS found that semaglutide alleviated autophagy and ovarian oxidative stress via the PI3K/AKT/mTOR (phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin) pathway [42] , further establishing a theoretical framework for the clinical application of GLP-1 RAs in PCOS