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At week 4, an 83% (11.1 U/day) reduction in TDD was due to a direct drug effect, and 17% (2.3 U/day) was attributed to weight loss, whereas at week 26, the difference was split evenly between direct effect (11.4 U/day

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A new generation of weight-loss drugs has proven remarkably effective, hugely popular and massively lucrative in the last few years, though they do have some drawbacks.