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Others have demonstrated that the positive outcomes of obesity surgery (i.e., changes in body weight and improved glucose homeostasis) are sustained in mice in the absence of GLP-1R or Y2-R, or both GLP-1R and Y2-R 66,67

Contrave : Across multiple clinical trials, people taking Contrave lost an average of 5%9% of their starting body weight over 56 weeks compared to placebo
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