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doi: 10.1161/CIRCULATIONAHA.119.044235

To understand how we are getting these longer-term effects, we need to study these drugs on a longer time scaleand thats exactly what we did. When the hormone GLP-1 finds a pancreatic beta cell, the ensuing chain of signals, proteins, and gene expression changes that lead to insulin secretion is very well documented

(1) SUV values for all individual time-frames were evaluated as potential endpoint for binding to the GCGR

ME-T: Methodology, Visualization, Formal Analysis, Investigation, Writing original draft, Writing review and editing

improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets

Following a [14C]sitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin