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We need to be honest about the significant lack of long-term studies for semaglutide

Report 2a: complications and mortality (complications of diabetes)

Semaglutide itself does not cause dehydration, but side effects like nausea and vomiting can lead to dehydration

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They discuss a case of a patient who presents with obstructive cardiogenic shock

But Retatrutides design carefully balances glucagon receptor activity in the presence of GLP-1 stimulation, and the net result is increased thermogenesis and energy expenditure rather than hyperglycemia