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12 Recent studies provide a direct demonstration of actions of central GLP-1 and show projections from GLP-1containing neurons in the NTS to the nucleus accumbens core and of satiation induced by injections of GLP-1 into this region of the accumbens

The results showed that Th1 cells polarized microglia towards high expression of INF response related genes ( Irf7 and Stat1 ), which further exacerbated the immune response in the later stages of neurodegenerative diseases

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37 Stimulating endogenous cardiomyocyte proliferation has been proposed as a more cautious yet promising approach, as direct activation of key signaling pathways has been shown to increase cardiomyocyte proliferation, despite the low basal turnover rate in adult mammalian hearts