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First, none of the trials included HF as a component of the primary composite endpoint (usually 3-component MACE)

Often when people gain weight, become obese or become diabetic, their levels of GLP-1 hormones go down, Burak said

Wang CA, Lin LC, Chen JY, Wang WJ, Wu VC

Visceral fat contributes to systemic inflammation, and chronic inflammation can worsen insulin resistance
The analysis of cardiovascular outcomes trials (CVOTs) revealed consistent benefits

26 JantrapiromS.NimlamoolW.ChattipakornN.ChattipakornS.TemviriyanukulP.InthachatW.et al (2020)
