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Recently, SGLT2i and GLP1- RAs have emerged as potential therapeutic tools preventing the transition from acute to chronic kidney disease due to their efficacy in preserving renal function

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The tradeoff: retatrutide appeared to show higher rates of nausea (42.4%), diarrhea (32.0%), and vomiting (25.3%) than tirzepatide or orforglipron at their top doses