retatrutide gut health How Does Work? Triple Agonist Explained Retatrutide vs Tirzepatide (2026): Differences
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Other diabetes drugs like SGLT2 inhibitors and metformin may also be used off-label for weight loss, but results are much more modest
In the SURPASS-2 head-to-head trial (Fras et al., NEJM 2021), tirzepatide 15mg reduced body weight 5.5kg more than semaglutide 1mg over 40 weeks in a type 2 diabetes population
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doi:10.2337/db15-1255 17
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