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doi: 10.1111/dom.13506 42 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

To date, the SURPASS program includes nine ongoing randomized controlled trials in patients with type2 diabetes: SURPASS 1 in monotherapy, SURPASS 2 versus semaglutide, SURPASS 3 versus degludec, SURPASS 4 versus glargine and established CV disease, SURPSS 5 basal insulin add-on, SURPASS AP- Combo versus glargine, and SURPASS-CVOT

Ban K, Noyan-Ashraf MH, Hoefer J, et al.: Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways

But Lilly is hitting a bigger market

ACE Inhibitors (Angiotensin-Converting Enzyme Inhibitors) Mechanism: Block conversion of Angiotensin I II vasoconstriction & aldosterone Examples: Enalapril, Lisinopril, Captopril Key Points: Protective in diabetic nephropathy, heart failure Caution: Avoid in pregnancy

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