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GLP-1 exerts anti-inflammatory effects by suppressing the NF-B signaling pathway, which leads to a decrease in the production of pro-inflammatory cytokines like TNF- and IL-6, thereby mitigating liver inflammation and fibrosis

glucagon receptor activation stimulates -oxidation of fatty acids, reducing hepatic lipid content, while GLP-1 enhances systemic insulin sensitivity and decreases lipolysis in adipose tissue, thereby indirectly reducing hepatic fat influx (51)

Quality Testing All medications are tested for potency every three to six months and must stay within 10% of the target strength

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Of note, in the STEP 1 extension trial, participants regained roughly two-thirds of their lost weight within a year of stopping semaglutide, and improvements in blood pressure, cholesterol, and glucose largely reversed
