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For humans, the model-predicted median clearance (CL) and volume of distribution (Vss) of semaglutide were 0.0397 L/h and 6.23 L, respectively

Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

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However, their effects on the digestive system raise important questions for people with Irritable Bowel Syndrome (IBS)