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In the STEP-HFpEF trial, 529 individuals with HFpEF and BMI 30 kg/m 2 were randomized to 2.4 mg semaglutide weekly versus placebo for 52 weeks

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In the action in diabetes and vascular disease (ADVANCE) trial, a study involving 11,140 subjects with T2DM who were followed for a median duration of 4.4 years, a higher HR was associated with a significantly increased risk of all-cause mortality, cardiovascular death, and major cardiovascular events (death, nonfatal acute myocardial infarction [AMI] or nonfatal stroke) [39]

Common side effects include mild gastrointestinal symptoms, which usually subside over time

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El tratamiento se inicia con la dosis ms baja durante el primer mes y, por lo general, se va aumentando hasta alcanzar la dosis ms alta al cabo de 5 meses