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He was surprised that although the [very low-calorie diet] resulted in greater reductions in weight, fat mass, and insulin resistance, it did not appear to enhance beta cell function. The authors suggest that this is because the participants had been living with type 2 diabetes for a long time

That distinction matters for researchers exploring dual-pathway approaches to metabolic regulation

Most people struggle with weight management, appetite control, and energy not because they lack willpower but because their GLP-1 system isn't getting the support it needs