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Nevertheless, increased J ATP was not observed in our previous paper with dietary-intervention induced weight loss (10)

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Between 2002 and 2012, the adult obesity rate in China increased from 29.9% to 42.0% ( Protein phosphorylation is essential for eukaryotic signaling and regulates the entire spectrum of life activities, including the cell cycle, development and differentiation, metabolism, and apoptosis, which is the most prevalent post-translational modification of proteins in cells ( In addition to glucose regulation, glucagon-like peptide-1 (GLP-1) is a essential entero-insulin in the body with glucose-concentration-dependent pro-insulin secretory properties and plays a significant role in synaptic plasticity and memory formation ( This study was the first to observe a difference in hippocampal phosphorylated protein expression in high-fat diet-induced obese mice before and after the intervention of semaglutide and empagliflozin using the phosphorylated 4D-LFQ technique, allowing researchers to further investigate the effects of both on hippocampal cognitive function in obese mice and provide a new basis for the precise prevention and treatment of obesity-related cognitive disorders