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Notably, GLP-1R is expressed in key areas of the mesolimbic system such as the ventral tegmental area, nucleus accumbens, and laterodorsal tegmental nucleus, 49 , 50 , 51 consistent with their regulation of neurobiological mechanisms that underlie the SUDs

What to actually do about it The strongest evidence for what changes the body composition equation comes from a randomized, head-to-head, placebo-controlled trial published by Lundgren and colleagues in NEJM in 2021

Therefore, clinicians should focus on individualized risk assessment, transparent counseling, and shared decision-making to guide appropriate therapy

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Diabetes 61 , 4048 (2012)

For example, the previous study that found changes in cell number maintained animals on a high-fat diet (36), whereas the other study provided a choice between chow and a high-fat diet (37), suggesting that the impact of VSG on intestinal hypertrophy depends on dietary exposure