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Dual GIP-GLP1-receptor agonists in the treatment of type 2 diabetes: a short review on emerging data and therapeutic potential

# # # Disclosures: Rohit Loomba, MD, is a consultant or advisory board member for Aardvark Therapeutics, Altimmune, Anylam/Regeneron, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Bristol-Myer Squibb, CohBar, Eli Lilly, Galmed, Gilead, Glympse bio, Hightide, Inipharma, Intercept, Inventiva, Ionis, Janssen Inc., Madrigal, Metacrine, Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Merck, Pfizer, Sagimet, Theratechnologies, 89 bio, Terns Pharmaceuticals and Viking Therapeutics

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Serving Size 2 Capsules Servings Per Container 30 Vitamin D3 (as cholecalciferol) 50 mcg (250% DV) Vitamin B6 (as pyridoxal 5'-phosphate) 26 mg (1,529% DV) Folate (from L-5-MTHF-Ca) 400 mcg DFE (100% DV) Vitamin B12 (as methylcobalamin) 525 mcg (21,875% DV) Biotin 5 mcg (17% DV) Iron (as ferrous bisglycinate chelate) 18 mg (100% DV) Magnesium (as magnesium oxide & citrate) 200 mg (48% DV) Zinc (as zinc bisglycinate chelate) 20 mg (182% DV) Digestive Comfort & Soothing Blend 325 mg ** Gingerols Ginger Root Extract (5% gingerols) Peppermint Leaf Extract Bromelain Powder (2,400 GDU/g) DigeZyme Multi-Enzyme Complex LactoSpore (Bacillus coagulans MTCC 5856) 166 mg (6B CFU) ** Energy & Vitality Complex 126 mg ** Ashwagandha Extract (root, 5% withanolides) Nutrient Replenishment Matrix 22 mg ** BioPerine Black Pepper Extract (fruit) 5 mg **

Listen to your body's hunger and fullness cues : GLP-1 medications help you feel full faster

In this regard, liraglutide has been shown to reduce the hepatic expression of PPAR- and, consequently, the intrahepatocyte accumulation of fatty acids, restoring the physiological lipid homeostasis [122,123]