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By forming a complex with bile acids that cannot be absorbed by the body, cholestyramine prevents recycling of bile acid through the process of enterohepatic recirculation

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While creatine supports muscle retention, semaglutide's effects on appetite and hydration may alter supplementation needs

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In clinical practice, drug selection should therefore prioritize factors such as tolerability, safety profile, adherence, cost, and patient preference rather than expecting major differences in cardiovascular efficacy.