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However, this approach is often labor-intensive, requiring extensive use of protecting groups, prolonged reaction times, and yielding side reactions like epimerization and dimerization, which lower the overall efficiency

Real-world evidence on the utilization, clinical and comparative effectiveness, and adverse effects of newer GLP-1RA-based weight-loss therapies

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Retatrutide was well tolerated and showed dose-dependent effects on lowering blood glucose levels, stimulating insulin secretion, suppressing glucagon secretion and reducing appetite in a phase 1 study involving healthy volunteers and patients with type 2 diabetes (Coskun et al., 2023b, Diabetes Care)

Research continues into additional applications

Statistical analysis was performed ANOVA (to analyse the difference between the means of more than two groups) or Students t test (to compare the means of specifically two groups), after normality was assessed by a Shapiro-Wilk test