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Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats

Patients should prepare to: Have regular checkups to tweak doses or monitor side effects

1 H ) without affecting expression of other genes, including PPAR , AdipoQ , ATGL , and HSL (Fig

usually most pronounced during dose escalation Diarrhea : Affects 12-17% of patients, typically mild to moderate in severity Vomiting : Reported in 6-10% of patients, more common at higher doses Constipation : Occurs in 6-11% of patients Abdominal pain and dyspepsia : Generally transient Decreased appetite : An expected pharmacological effect contributing to weight loss Other documented adverse effects include injection site reactions, hypoglycemia (when used with insulin or sulfonylureas), and less commonly, fatigue

Statistical analyses were performed using GraphPad software (San Diego, CA, USA)

Recommended maintenance dose for weight loss: 5 mg, 10 mg, or 15 mg injected subcutaneously once weekly