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As GLP-1 medications improve blood sugar and insulin levels, they may actually help reduce the acidity of the urine, potentially lowering the risk of uric acid stones over time

But when the FDA declared an end to the shortage, it closed the loophole that allowed compounders to produce copycats

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Similarly, when abliglutide was used in patients with known HFrEF, no improvement was noted in LVEF (left ventricular ejection fraction) [28]

The American Diabetes Association Standards of Care acknowledge gastrointestinal tolerability as a key consideration when initiating GLP-1 receptor agonist therapy, recommending gradual dose titration to minimize these effects