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Within the first few weeks, a change in appetite may be noticeable, but a significant weight change may not yet be apparent

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Thus, these in vitro findings indicate that the beneficial effect of incretin receptor agonists on fibrosis progression in MASLD patients is likely to be mediated indirectly through improvements in body weight, inflammation, and insulin resistance, rather than through the direct action on hepatic parenchymal or non-parenchymal cells

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