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KFF polling puts it at 29M whove tried one, with 14M still on therapy (source)

NICE guidance (NG28) recommends GLP-1 receptor agonists for adults with type 2 diabetes according to specific criteria, including BMI thresholds and previous therapy response

Collaboration with PBMs and providers

Diabetes approvals may accept BMI 25

Unlike insurance claims data, which tend to reflect usage among diabetic or obese patients with treatment covered by insurance, Numerators data also capture households that use GLP-1 drugs off-label, including many who pay out of pocket and do not meet the clinical criteria for obesity, providing a broader view of adoption patterns

The SURMOUNT-5 trial found approximately 20.2% average body-weight loss with branded tirzepatide versus 13.7% with branded semaglutide over 72 weeks in adults with obesity and without diabetes