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Description
A1 astrocytes lose the ability to promote neuronal survival, outgrowth, synaptogenesis, and phagocytosis and induces the death of neurons and oligodendrocytes [134]

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Analysis software Modeling and simulation were conducted using NONMEM 7.4 (ICON Development Solutions, USA), and model parameter estimation was performed using the First-Order Conditional Estimation method (FOCE-I)

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