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So I think whats interesting is it also immune modulating because mast cells have GLP receptors

Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function

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Further, the targeting construct used for the knock-in model enabled creation of Glp-1r / mice derived via Cre-mediated deletion of the hGLP-1R

Mechanisms for Surgery-Induced Increases in GLP-1 The mechanisms leading to substantial postprandial release of gut peptides, particularly GLP-1, after bariatric surgery are thought to be largely a consequence of rapid nutrient delivery further down in the GI tract, where the majority of L-cells are located

Research suggests these drugs may cause depressive symptoms by lowering cholesterol levels in the brain