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Within this framework, the PKA pathway is central: cAMP activation triggers PKA, which promotes protein secretion, facilitates fluid secretion by elevating intracellular calcium levels, and activates cAMP response elementbinding protein (CREB), a key transcription factor coordinating these downstream signaling events [73]

Understanding this nuanced risk-benefit profile enables informed shared decision-making between healthcare providers and patients considering GLP-1 therapy
& Gutmann, H

therefore, DPP-4 inhibitors are used as glucose-lowering agents in individuals with type 2 diabetes [8]