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Methotrexate, used to treat rheumatoid arthritis and other autoimmune conditions, works through immunosuppression and cell-cycle disruptionbut appetite loss is a common and often unavoidable side effect

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Rare problems include bleeding, a leak from where the stomach or intestines were joined, a narrowing (scar tissue) that makes food harder to pass and blood clots

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Compounded semaglutide is injected subcutaneously (under the skin) in the stomach (abdomen), thigh, or upper arm