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10,23,24 Similarly, there was no increased risk of pancreatic cancer associated with GLP-1RAs in a large cohort study and a 2020 meta-analysis

48 As an add-on to insulin with or without metformin (PIONEER 8), oral semaglutide (at doses of 3, 7 and 14 mg) was shown to be associated with superior HbA1c and body weight reductions versus placebo as early as at week 26 and achieved further reduction in insulin need (except dose 3 mg) at week 52, without significantly increasing the rate of hypoglycemia

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At baseline, EAT attenuation was 80 HU and PCAT attenuation of the right coronary artery (RCA) was 68 HU, values associated with an increased cardiac mortality risk