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Description
An essential component of this transepithelial transport system is the co-transporter, SGLT-1, which uses the sodium electrochemical gradient produced by the Na + /K + ATPase pump to allow glucose entry across the apical membrane and into enterocytes (178, 179)

When GLP-1 receptor agonists are combined with insulin or sulfonylureas, the doses of these medications may need to be reduced to avoid hypoglycemia

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Karlsson D, Ahnmark A, Sabirsh A, Andrasson AC, Gennemark P, Sandinge AS, et al (2022) Inhibition of SGLT2 preserves function and promotes proliferation of human islets cells in vivo in diabetic mice
