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As cardiovascular risk remains high among adults with type 2 diabetes and excess weight, the timely evaluation of new therapies is a public health priority

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The drug was first approved for that purpose in 2017 and was then approved as a type 2 diabetes pill called Rybelsus and, most recently, as an injection to treat obesity called Wegovy

A comparison between the water-soluble glucagon receptor monoagonist glucagon CEX (Gcg CEX) and the GLP-1R mono-agonist exendin-4 at 1 mol/kg/day in diet-induced obesity mice demonstrated nearly equivalent degrees of body weight loss and improvements in glucose metabolism, both without signs of fasting hyperglycemia [9]

The scoping review method was selected to map the different types of evidence on the topic, summarize research findings, and identify gaps that warrant further research [7]

Anyone else seeing this tension in practice