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NAFLD is currently treated by reducing weight and improving insulin resistance through lifestyle interventions [8]

Compared to the LEADER trial, the follow-up time in EXSCEL was much shorter (3.2 years vs

The medical decisions about which dose to target are individual

Methods We searched PubMed, Embase, Cochrane and ClinicalTrials.gov up until 27 October 2021 for randomised controlled trials with a duration of at least 12 weeks that compared once-weekly tirzepatide 5, 10 or 15 mg with placebo or other glucose-lowering drugs in adults with type 2 diabetes irrespective of their background glucose-lowering treatment

3 In fact, the effects of GIPR activation on glycemia and body weight have been controversial

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