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DOI: 10.1056/NEJMoa2301972 Sanyal AJ, et al
Freezing semaglutide destroys the peptide structure through ice crystal formation, making the medication ineffective and potentially unsafe

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The study was approved by the Cleveland Clinic Enterprise institutional review board and was registered on ClinicalTrials.gov (NCT06533527)

By targeting these general mechanisms, drugs can exert specific effects in definite diseases, repairing disrupted processes precisely where they occur
Protein-rich foods work synergistically with this effect because they trigger stronger satiety signals and preserve lean muscle during weight loss
