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It affects the GLP one receptor but also the GIP receptor, which are both involved in hunger and satiety and motility. Dan Azagury, MD, FACS, the chief bariatric surgeon and medical director of Stanford University School of Medicines Lifestyle and Weight Management Clinic in California, who also was not involved in the Eli Lilly study, told Healthline that he was not surprised at the studys results

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Future NDD trials will likely need biological enrichment strategies (e.g., selecting BIR-positive or metabolically dysregulated individuals), combined with biomarker endpoints of central insulin signaling and stringent adherence frameworks, to reliably identify responders

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