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Background GLP-1R agonists protect the blood-brain barrier (BBB): These drugs help maintain the integrity of the BBB by preventing tight junction degradation, which can reduce the risk of neuroinflammation and cognitive decline

However, Medicare through Aetna will not cover Ozempic as a weight loss drug

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For multi-dose pens (Ozempic, Victoza, Saxenda, Byetta), it is important to write the date of first use on the pen label to track how long it has been in use

Hypoglycemia with Concomitant Use of Insulin or Insulin Secretagogues Inform patients that the incidence of hypoglycemia may increase when XIGDUO XR is added to an insulin secretagogue (e.g., sulfonylurea) and/or insulin