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Reductions in lipids and CV risk markers in patients with type 2 diabetes treated with liraglutide: a meta-analysis

These medications affect weight loss through multiple mechanisms: Appetite Regulation: GLP-1 medications interact with brain receptors that control hunger signals, helping reduce food cravings and overall calorie intake Blood Sugar Management: These medications improve blood sugar levels by enhancing insulin secretion when blood glucose is elevated Gastric Emptying: GLP-1 medications slow the movement of food from the stomach to the small intestine, promoting feelings of fullness Metabolic Effects: These drugs can influence metabolic rate and fat storage patterns in ways that support sustainable weight loss These combined effects can lead to significant weight reduction when used as part of a comprehensive treatment plan that includes lifestyle modifications

Qualitative research consistently shows that individuals with obesity often report long-standing experiences of devaluation or exclusion, contributing to shame-based self-representations and defensive patterns such as withdrawal or minimization [82,83,84,85]

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For example, in the LEADER trial, when compared with placebo, liraglutide decreased the incidence of major cardiovascular events (MACE) by 13%, cardiovascular death by 22% and all-cause death by 15% among T2DM patients with CVD, on a standard treatment basis [4]

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