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SGLT2is shift the hearts energy metabolism toward more efficient substrates like KB, which improve myocardial energy efficiency and reduce stress on heart muscle cells, upregulating the fatty acid metabolism [108,109]

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During treatment, the one-year incidence of events was 1.3% for acute coronary syndromes, 13.2% for coronary artery disease, 7.3% for heart failure, 1.9% for stroke, and 0.06% for all-cause mortality

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Occasional one-day adjustments are noise in the signal

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