pfizer oral glp 1 to discontinue danuglipron, its GLP-1 pill for obesity| STAT Pfizer discontinues oral GLP-1 receptor

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Key pharmacological effects include: Glucose-dependent insulin secretion Enhanced pancreatic beta-cell insulin release only when blood glucose is elevated, reducing hypoglycemia risk Suppression of glucagon secretion Decreased hepatic glucose production from pancreatic alpha cells Delayed gastric emptying Slowed movement of food from the stomach to the small intestine Central appetite regulation Reduced hunger and increased satiety through hypothalamic pathways The delayed gastric emptying effect is particularly significant and represents both a therapeutic mechanism and a potential source of adverse effects

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[DOI] [PMC free article] [PubMed] [Google Scholar] 165.Heymsfield SB, Shapses SA

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Hunot S, Brugg B, Ricard D, Michel PP, Muriel MP, Ruberg M, et al