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reported that cleavage products derived from GLP-1 reduced tubulointerstitial renal damage, lowered the expression of tubular injury markers, and attenuated the renal accumulation of macrophages and T cells ( Glycemic Control Although the glucose-independent mechanisms are emphasized, glycemic control by GLP-1RAs is considered to be involved in its renoprotective effects

doi:10.1111/j.1365-2982.2010.01476.x Panjwani N, Mulvihill EE, Longuet C, et al

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Once in circulation, GLP-1 travels to target tissues, including the pancreas, where it enhances insulin secretion, and the brain, where it promotes satiety

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