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However, liraglutide achieved this primarily through a pronounced reduction in palatable food intake, whereas sibutramine reduced consumption of both chow and palatable foods (Hansen et al., 2012)

People with treatment-resistant hypertension, especially those with co-existing diabetes, obesity, heart failure (HF), or chronic kidney disease (CKD) may particularly benefit from SGLT2-i and GLP-1RA

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These developments follow decades of research since the discovery of GLP-1 in the 1980s and the subsequent engineering of stable, long-acting analogs