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We did not require elevated NT-proBNP as an eligibility criterion, and thus, NT-proBNP levels in SUMMIT were only slightly elevated on average (median 175 ng l 1 ), and accordingly, there was little margin for further reduction

These hormones are secreted after meals and contribute to the regulation of glucose and fat metabolism

This directional check catches most calculation errors before they result in incorrect dosing

The mechanism is complementary to GLP-1 effects, and some practitioners use it alongside peptide-based weight loss approaches

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Potential risks may include: Overdosing, which may lead to symptoms such as nausea, vomiting, or other adverse effects