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Despite reduced food intake, patients must ensure adequate micronutrient consumption, including: Calcium and vitamin D for bone health Iron and B vitamins for energy metabolism Adequate fibre for digestive health Regular monitoring by healthcare professionals is essential

The most common bodys natural response to the medication is a gastrointestinal issue, such as nausea, vomiting, diarrhea, or constipation

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These symptoms could indicate gastroparesis (severely delayed stomach emptying) or other complications requiring medical assessment

7.2 Comparing with the novel metabolic target drugs As the FXR-activating function of GLP-1RAs, FXR agonists may have the same effect as GLP-1RAs ( In reducing the risk of major adverse liver outcomes and HCC, large-scale observational studies and meta-analyses have demonstrated that GLP-1RA and SGLT2i exhibit comparable protective effects, with both showing significant superiority over traditional hypoglycemic agents such as DPP-4i and sulfonylureas

Providers should use the opportunity of GLP-1 receptor agonist switching to re-educate patients about the mechanisms of action and set patient expectations, especially with respect to the effects of delayed gastric emptying