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Description
This narrative review summarises the role of incretin mimetics, individually or in combination therapy, in the treatment of MASLD/MASHhighlighting the pathophysiology and mechanisms of action, recent evidence from phase 2 and 3 MASH clinical trials, and clinical benefits

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In healthy subjects, oral glucose triggers a stronger insulin secretion response than intravenous glucose because of the secretion of incretin from the gastrointestinal tract, known as the incretin effect. Clinically, incretin-based drugs include glucagon-like peptide 1 receptor agonists (GLP-1 RA) (such as liraglutide) and dipeptidyl peptidase 4 inhibitors (DPP-4i) (such as vildagliptin)

The global GLP-1 market is forecasted to exceed $100 billion by 2030, driven by both diabetes and obesity treatment needs and the effectiveness of these medications in regulating blood sugar and appetite suppressant
