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2022;34(2):317328.e6

13 In other words, GLP-1 medicines reduce disease complications directly and indirectly in overlapping ways, perhaps most importantly by reducing chronic inflammation

This approach aims to attenuate these responses and leverage a potential metabolic advantage (higher energy expenditure), particularly in insulin-resistant states, while helping to recalibrate the homeostasis of the brains hungersatiety circuits

It means that even if a patch contains a clinically studied ingredient, that ingredient may not be reaching the bloodstream in any meaningful amount (7)

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Milicevic, Z