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There is no data to suggest that the weight regain will not happen
In addition, the annual eGFR decline was lower for semaglutide by 1.16 mL/min/1.73 m 2 compared with placebo (15)

Nature Reviews Endocrinology, 8, 728-42
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Two pathways exist
Kappe C, Fransson L, Wolbert P, Ortster H