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In clinical trials, people using GLP-1 drugs lost an average of about 10 pounds more than people using a placebo

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Methods In the PIONEER trials, people with type 2 diabetes were randomised to orally administered semaglutide versus placebo (PIONEER 1, 4, 5 and 8), empagliflozin (PIONEER 2), sitagliptin (PIONEER 3) and liraglutide (PIONEER 4) for 2678 weeks

- Mechanism of Action & Protocol.

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