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A systematic review reported no associations between GLP-1RAs and serious psychiatric effects, including psychosis, major depression, or suicide

They are commonly used in provider-guided wellness protocols designed to support balanced eating habits, nutrient utilization, and overall metabolic efficiency
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Naltrexone-Bupropion (Contrave) Contrave combines naltrexone, used to treat addiction, with bupropion, an antidepressant

Microbiota effects may also contribute to the extra-glycemic benefits of cardiovascular and kidney protection, and anti-inflammatory activity
