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What Is the FDA Worried About

As triple-board-certified endocrinologist and obesity specialist Dr

GLP-1 is a member of the incretin neuropeptide family, secreted by intestinal enteroendocrine L-cells of the distal ileum and large intestine [4, 5] and also in the nucleus of the solitary tract (NTS) in response to nutrient intake [6, 7]

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These mechanisms further activate the hypothalamic-pituitary-adrenal axis, hepatic glycogenolysis, hyperglycemia, hyperlipidemia, and insulin resistance, contributing to core depressive features of anhedonia, emotional dysregulation, and cognitive slowing ( The complex etiopathogenesis of T2DM has been explored in detail and includes insulin resistance (in the liver, muscles, and adipose tissue), impaired insulin secretion, -cell dysfunction, immune dysregulation and meta-inflammation, hyperglucagonemia, disrupted gut microbiota, increased gastric glucose absorption, renal adaptation with enhanced glucose reabsorption and gluconeogenesis, decreased dopamine, and heightened sympathetic tone in the brain ( via cells of the circumventricular organs located around the third and fourth brain ventricles, transmitting signals to deeper brain structures