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At 72 weeks, participants receiving the 5 mg, 10 mg, and 15 mg doses of Tirzepatide achieved mean percentage weight reductions of 15.0%, 19.5%, and 20.9%, respectively, compared to a 3.1% reduction in the placebo group

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Because tirzepatide already stimulates both GLP-1 and GIP pathways, adding a GLP-1only agent (semaglutide) would create redundancy on the GLP-1 receptor without activating any new biological target

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The cytotoxic effect of various concentrations of aqueous turmeric root extract, nutritional supplement capsules, and curcumin toward Vero E6 cells was determined by Orangu Cell Counting Solution (Cell guidance systems) after 48 h